SS-31 (Elamipretide, MTP-131) is a reference tetrapeptide from the class of Szeto-Schiller peptides, designed for selective accumulation in the inner mitochondrial membrane. A characteristic structural feature is the alternation of aromatic and basic amino acids, which allows penetration of the lipid bilayer in in-vitro models.
Investigated Biochemical Pathways (Academic Context)
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Cardiolipin binding: in-vitro models of interaction with cardiolipin as a unique phospholipid of the inner mitochondrial membrane; stabilization of respiratory supercomplexes (I/III/IV).
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Mitochondrial ROS assays: in-vitro characterization of reactive oxygen species production in isolated mitochondrial preparations.
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Ischemia-reperfusion in-vitro models: interaction with mitochondrial membranes in ischemia-reperfusion models of isolated cardiomyocyte cultures.
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Skeletal muscle in-vitro models: characterization of mitochondrial function in myocyte cultures within the research area of age-related muscle atrophy (sarcopenia as a research area).
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Renal in-vitro models: characterization of tubular cell cultures in experimental models of oxidative stress.
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Neuronal in-vitro models: SS-31 is being investigated within the academic research of mitochondrial dysfunction in isolated neuronal cultures.
Laboratory Use and Storage
Suitable as a reference standard for HPLC, MS, and in-vitro mitochondrial assays. In laboratory practice, lyophilized peptides are handled using suitable sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. Store the lyophilized product at -20 °C, protected from light and moisture.
Product Purpose
This material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, skin application, ingestion, inhalation, or veterinary purposes. It is not a medicine, food supplement, cosmetic, or medical device.
Access
Sales are subject to confirmation of age 18+ and declaration of research or collection purpose upon completion of the order.
