Retatrutide (LY3437943) is a reference synthetic peptide multidomain analog from the class of multi-receptor incretin agonists. In published literature, it is described as the first molecule of its kind to simultaneously activate three receptor systems: GIP receptor (GIPR), GLP-1 receptor (GLP-1R), and glucagon receptor (GCGR).
Investigated Biochemical Pathways (Academic Context)
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Triple Receptor Agonism: in-vitro receptor binding assays on cloned GIPR/GLP-1R/GCGR receptors and characterization of signaling cascades (cAMP responses).
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Incretin Metabolic Research: academic interest in the research area of metabolic diseases (including diabetes mellitus and obesity as research areas).
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Modulation of AMPK signaling: in-vitro models of glucose utilization and fatty acid oxidation at the level of isolated hepatocyte and adipocyte cultures (e.g., within the research area of fatty liver disease).
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Extended Pharmacokinetics: binding interaction of the C20-acyl chain with albumin; subject of pharmacokinetic research at the in-vitro model level.
Laboratory Use and Storage
Suitable as a reference standard for HPLC, MS, and in-vitro receptor assays. In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. To maintain the stability of the material's structure, cold storage and protection from light are recommended.
Product Purpose
This material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, application to the skin, ingestion, inhalation, or veterinary purposes. It is not a medicine, food supplement, cosmetic, or medical device.
Access
Sales are subject to confirmation of age 18+ and declaration of research or collector's purpose upon completion of the order.
