MOTS-c (Mitochondrial Open reading frame of the twelve S rRNA-c) is a reference synthetic 16-amino acid peptide identified in 2015 by a research team from USC (University of Southern California). In academic literature, it is referenced as the first peptide directly encoded by the mitochondrial genome from a new class of signaling molecules referred to as "mitokines".
Investigated Biochemical Pathways (Academic Context)
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Mitochondrial-Nuclear Signaling: academic interest in peptide translocation into the cytoplasm and nucleus in in-vitro cell models.
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Modulation of AMPK Signaling: in-vitro models of glucose and fatty acid utilization at the level of isolated hepatocyte and myocyte cultures.
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Skeletal Muscle In-Vitro Models: characterization of interaction with myocyte lines within the academic research area of age-related atrophy (sarcopenia as a research area).
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NF-κB Signaling: in-vitro modulation of the NF-κB transcription factor in isolated immune cells.
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Neuronal In-Vitro Models: academic interest in protecting mitochondrial function in isolated neuronal cultures in the context of neurodegenerative disease research.
Laboratory Use and Storage
Suitable as a reference standard for HPLC, MS and in-vitro cell assays. In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. Store lyophilized material at -20 °C, protected from light and moisture.
Product Purpose
This material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, skin application, ingestion, inhalation, or veterinary purposes. It is not a drug, dietary supplement, cosmetic, or medical device.
Access
Sales are subject to age verification (18+) and declaration of research or collector's purpose upon order completion.
Storage and Handling
In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. To maintain the stability of the material's structure, storage in a cool place and protection from light are recommended.
