{"title":"Metabolic research","description":"","products":[{"product_id":"g-l-p-3-10-mg","title":"GLP-3","description":"\u003cp data-start=\"0\" data-end=\"323\" class=\"PDq2pG_selectionAnchorContainer\"\u003eGLP-3 (LY3437943) is a reference synthetic peptide multidomain analog from the class of multi-receptor incretin agonists. In published literature, it is described as the first molecule of its kind to simultaneously activate three receptor systems: GIP receptor (GIPR), GLP-1 receptor (GLP-1R), and glucagon receptor (GCGR).\u003cspan aria-hidden=\"true\" class=\"PDq2pG_selectionAnchor\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-section-id=\"1wo6p3a\" data-start=\"325\" data-end=\"380\"\u003eInvestigated Biochemical Pathways (Academic Context)\u003c\/h2\u003e\n\u003cp data-start=\"382\" data-end=\"546\"\u003e\u003cstrong data-start=\"382\" data-end=\"410\"\u003eTriple Receptor Agonism:\u003c\/strong\u003e\u0026nbsp;in-vitro receptor binding assays on cloned GIPR\/GLP-1R\/GCGR receptors and characterization of signaling cascades (cAMP responses).\u003c\/p\u003e\n\u003cp data-start=\"548\" data-end=\"707\"\u003e\u003cstrong data-start=\"548\" data-end=\"580\"\u003eIncretin Metabolic Research:\u003c\/strong\u003e\u0026nbsp;academic interest in the research area of metabolic diseases (including diabetes mellitus and obesity as research areas).\u003c\/p\u003e\n\u003cp data-start=\"709\" data-end=\"927\"\u003e\u003cstrong data-start=\"709\" data-end=\"742\"\u003eModulation of AMPK signaling:\u003c\/strong\u003e\u0026nbsp;in-vitro models of glucose utilization and fatty acid oxidation at the level of isolated hepatocyte and adipocyte cultures (e.g., within the research area of fatty liver disease).\u003c\/p\u003e\n\u003cp data-start=\"929\" data-end=\"1085\"\u003e\u003cstrong data-start=\"929\" data-end=\"959\"\u003eExtended Pharmacokinetics:\u003c\/strong\u003e\u0026nbsp;binding interaction of the C20-acyl chain with albumin; subject of pharmacokinetic research at the in-vitro model level.\u003c\/p\u003e\n\u003ch2 data-section-id=\"1yg0v9z\" data-start=\"1087\" data-end=\"1116\"\u003eLaboratory Use and Storage\u003c\/h2\u003e\n\u003cp data-start=\"1118\" data-end=\"1518\"\u003eSuitable as a reference standard for HPLC, MS, and in-vitro receptor assays. In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. To maintain the stability of the material's structure, cold storage and protection from light are recommended.\u003c\/p\u003e\n\u003ch2 data-section-id=\"toapjk\" data-start=\"1520\" data-end=\"1538\"\u003eProduct Purpose\u003c\/h2\u003e\n\u003cp data-start=\"1540\" data-end=\"1882\"\u003eThis material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, application to the skin, ingestion, inhalation, or veterinary purposes. It is not a medicine, food supplement, cosmetic, or medical device.\u003c\/p\u003e\n\u003ch2 data-section-id=\"zyi10h\" data-start=\"1884\" data-end=\"1893\"\u003eAccess\u003c\/h2\u003e\n\u003cp data-start=\"1895\" data-end=\"2020\" data-is-last-node=\"\" data-is-only-node=\"\"\u003eSales are subject to confirmation of age 18+ and declaration of research or collector's purpose upon completion of the order.\u003c\/p\u003e","brand":"Cerebrotech","offers":[{"title":"10 mg","offer_id":54300886106441,"sku":null,"price":138.99,"currency_code":"EUR","in_stock":true},{"title":"20 mg","offer_id":54300886139209,"sku":null,"price":223.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0997\/6289\/7225\/files\/GLP-3.jpg?v=1782645311"},{"product_id":"cagrilintide-5-mg-prasok","title":"Cagrilintide 5 mg – Powder","description":"\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003eCagrilintide is a synthetic reference peptide analog of amylin with an added eicosanoic (C20 diacid) side chain allowing albumin binding. It is described in published literature as an agonist of heterodimeric amylin receptor complexes AMY1-3 (calcitonin receptor in combination with RAMPs).\u003c\/p\u003e\n\u003ch2 id=\"skman-biochemick-drhy-akademick-kontext\" class=\"font-editorial font-bold mb-2 mt-4 [.has-inline-images_\u0026amp;]:clear-end text-base first:mt-0\"\u003eInvestigated biochemical pathways (academic context)\u003c\/h2\u003e\n\u003cul class=\"marker:text-quiet list-disc pl-8\"\u003e\n\n\u003cli class=\"py-0 my-0 prose-p:pt-0 prose-p:mb-2 prose-p:my-0 [\u0026amp;\u0026gt;p]:pt-0 [\u0026amp;\u0026gt;p]:mb-2 [\u0026amp;\u0026gt;p]:my-0\"\u003e\n\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003e\u003cstrong\u003eAMY1-3 receptor agonism:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ein-vitro binding assays on cloned AMY receptor complexes.\u003c\/p\u003e\n\n\n\u003c\/li\u003e\n\n\u003cli class=\"py-0 my-0 prose-p:pt-0 prose-p:mb-2 prose-p:my-0 [\u0026amp;\u0026gt;p]:pt-0 [\u0026amp;\u0026gt;p]:mb-2 [\u0026amp;\u0026gt;p]:my-0\"\u003e\n\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003e\u003cstrong\u003eReceptor pharmacology:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003echaracterization of signaling cascades in isolated cell models.\u003c\/p\u003e\n\n\n\u003c\/li\u003e\n\n\u003cli class=\"py-0 my-0 prose-p:pt-0 prose-p:mb-2 prose-p:my-0 [\u0026amp;\u0026gt;p]:pt-0 [\u0026amp;\u0026gt;p]:mb-2 [\u0026amp;\u0026gt;p]:my-0\"\u003e\n\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003e\u003cstrong\u003eAcademic research area:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ereferenced in studies of energy homeostasis regulation within the research area of metabolic diseases.\u003c\/p\u003e\n\n\n\u003c\/li\u003e\n\n\u003cli class=\"py-0 my-0 prose-p:pt-0 prose-p:mb-2 prose-p:my-0 [\u0026amp;\u0026gt;p]:pt-0 [\u0026amp;\u0026gt;p]:mb-2 [\u0026amp;\u0026gt;p]:my-0\"\u003e\n\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003e\u003cstrong\u003eExtended pharmacokinetics:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ein-vitro models of albumin binding as a subject of pharmacokinetic research.\u003c\/p\u003e\n\n\n\u003c\/li\u003e\n\n\u003cli class=\"py-0 my-0 prose-p:pt-0 prose-p:mb-2 prose-p:my-0 [\u0026amp;\u0026gt;p]:pt-0 [\u0026amp;\u0026gt;p]:mb-2 [\u0026amp;\u0026gt;p]:my-0\"\u003e\n\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003e\u003cstrong\u003eCombination studies:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eacademic interest in synergy with GLP-1 agonists (e.g., the so-called CagriSema combination) at the level of in-vitro models.\u003c\/p\u003e\n\n\n\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003ch2 id=\"laboratrne-pouitie-a-skladovanie\" class=\"font-editorial font-bold mb-2 mt-4 [.has-inline-images_\u0026amp;]:clear-end text-base first:mt-0\"\u003eLaboratory use and storage\u003c\/h2\u003e\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003eSuitable as a reference standard for HPLC and in-vitro receptor assays. In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as \u003ca href=\"\/en\/products\/bakteriostaticka-voda-10-ml\"\u003e\u003cb\u003eBacteriostatic Water - 10 ml\u003c\/b\u003e\u003c\/a\u003e. Store lyophilized material at -20 °C, protected from light.\u003c\/p\u003e\n\u003ch2 id=\"el-produktu\" class=\"font-editorial font-bold mb-2 mt-4 [.has-inline-images_\u0026amp;]:clear-end text-base first:mt-0\"\u003eProduct purpose\u003c\/h2\u003e\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003eThis material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, topical application, ingestion, inhalation, or veterinary purposes. It is not a medicine, dietary supplement, cosmetic, or medical device.\u003c\/p\u003e\n\u003ch2 id=\"prstup\" class=\"font-editorial font-bold mb-2 mt-4 [.has-inline-images_\u0026amp;]:clear-end text-base first:mt-0\"\u003eAccess\u003c\/h2\u003e\n\u003cp class=\"my-2 [\u0026amp;+p]:mt-4 [\u0026amp;_strong:has(+br)]:inline-block [\u0026amp;_strong:has(+br)]:pb-2\"\u003eSales are subject to confirmation of age 18+ and declaration of research or collection purpose upon order completion.\u003c\/p\u003e\n\u003cp data-path-to-node=\"9\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9\"\u003eStorage and handling\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"9\"\u003eIn laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as \u003ca href=\"\/en\/products\/bakteriostaticka-voda-10-ml\"\u003e\u003cb\u003eBacteriostatic Water - 10 ml\u003c\/b\u003e\u003c\/a\u003e. To maintain the stability of the material's structure, cold storage and protection from light are recommended.\u003c\/p\u003e","brand":"Cerebrotech","offers":[{"title":"Default Title","offer_id":54061083361609,"sku":null,"price":80.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0997\/6289\/7225\/files\/Cagrilintide.jpg?v=1777644151"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0997\/6289\/7225\/collections\/Gemini_Generated_Image_o4dvtio4dvtio4dv.png?v=1776355694","url":"https:\/\/cerebrotech.eu\/en\/collections\/vyskum-chudnutia-a-metabolizmu.oembed","provider":"Cerebrotech","version":"1.0","type":"link"}